This technical manual, published in 2018, explores the intricate subject of Molecular Evolution on Rugged Landscapes, focusing on Protein, RNA, and the Immune System. It delves into complex topics such as rugged fitness landscapes, somatic mutation, and the hypercycle model, offering a comprehensive examination of these scientific principles. The content is designed for graduate students and professionals in immunology, population biology, physics, and molecular biology, providing insights into the mathematical and experimental aspects of biomolecule evolution for medical and industrial applications.
This document serves as a detailed technical resource, covering the primary topic of rugged fitness landscapes and secondary topics including molecular and protein evolution, RNA evolution, and the immune system. It is structured into sections addressing general issues, experimental work on somatic mutation and immune response maturation, and the hypercycle model. The manual is written in English and comprises 328 pages, offering a thorough exploration of its subject matter for advanced study and research.
Rugged fitness landscapes, and emerging area of biological science, underline both molecular and morphological evolution. Mathematical descriptions of such landscapes can be expected to lead to new experimental studies that actually test and establish their structure. In addition, current experimental techniques now allow one to carry out applied molecular evolution in the laboratory, opening up the possibility of evolving biomolecules for medical and industrial use. Molecular Evolution on Rugged Fitness Landscapes, based on a Santa Fe Institute workshop, is the first book to serve as a comprehensive introduction to these tools that permit researchers to study the structures of complex, rugged, multipeaked fitness landscapes.The first section of the book outlines a number of the general issues concerning the structure of rugged fitness landscapes. The second section examines both the history and status of experimental work on somatic mutation and the maturation of the immune response, and discusses the hypercycle model of the origin of life. This proceedings volume is an excellent reference for graduate students and professionals in immunology, population biology, physics and molecular biology.
Author: Perelson, Alan S.
Publisher: CRC Press
Illustration: N
Language: ENG
Title: Molecular Evolution on Rugged Landscapes: Protein, RNA, and the Immune System (Volume IX)
Pages: 00328 (Encrypted PDF)
On Sale: 2018-03-08
SKU-13/ISBN: 9780201521504
Category: Science : Life Sciences - General
Rugged fitness landscapes, and emerging area of biological science, underline both molecular and morphological evolution. Mathematical descriptions of such landscapes can be expected to lead to new experimental studies that actually test and establish their structure. In addition, current experimental techniques now allow one to carry out applied molecular evolution in the laboratory, opening up the possibility of evolving biomolecules for medical and industrial use. Molecular Evolution on Rugged Fitness Landscapes, based on a Santa Fe Institute workshop, is the first book to serve as a comprehensive introduction to these tools that permit researchers to study the structures of complex, rugged, multipeaked fitness landscapes.The first section of the book outlines a number of the general issues concerning the structure of rugged fitness landscapes. The second section examines both the history and status of experimental work on somatic mutation and the maturation of the immune response, and discusses the hypercycle model of the origin of life. This proceedings volume is an excellent reference for graduate students and professionals in immunology, population biology, physics and molecular biology.
Author: Perelson, Alan S.
Publisher: CRC Press
Illustration: N
Language: ENG
Title: Molecular Evolution on Rugged Landscapes: Protein, RNA, and the Immune System (Volume IX)
Pages: 00328 (Encrypted PDF)
On Sale: 2018-03-08
SKU-13/ISBN: 9780201521504
Category: Science : Life Sciences - General
